Study Overview

The Speech, Voice, and Communication Study examines how brain and behavioral differences affect speech, voice, and communication in individuals with 16p11.2 chromosomal deletion syndrome. Many people with 16p11.2 deletions experience speech and language differences that may relate to sensorimotor and neurobiological factors influencing how the brain controls speech and vocal expression.

Participants ages 8–17, with fluent or developing spoken language, complete speech, voice, and developmental assessments and noninvasive brain imaging (MRI and MEG). By comparing individuals with 16p11.2 deletions, autism spectrum disorder, and typically developing peers, researchers aim to identify shared and distinct neural mechanisms underlying communication differences.

Findings from this work will guide the development of targeted, mechanism-based interventions to support speech and communication in neurodevelopmental conditions.